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Asian Cardiovasc Thorac Ann 2002;10:150-154
© 2002 Asia Publishing EXchange Pte Ltd

ORIGINAL CONTRIBUTIONS

Thymoma Associated With Pure Red-Cell Aplasia: Clinical Features and Prognosis

Tomohiro Murakawa, MD, Jun Nakajima, MD, Hajime Sato, MD1, Makoto Tanaka, MD, Shinichi Takamoto, MD, Masashi Fukayama, MD2

Department of Cardiothoracic Surgery
1 Department of Public Health
2 Department of Pathology Faculty of Medicine University of Tokyo Tokyo, Japan
Tomohiro Murakawa, MD Tel: 81 3 5800 8654 Fax: 81 3 5684 3989 email: murakawa-tky{at}umin.ac.jp Department of Cardiothoracic Surgery, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
As information on the clinical features and prognosis of thymoma complicated by pure red-cell aplasia is limited, follow-up data on thymoma patients who had a thymectomy between 1954 and 1999 were analyzed retrospectively. Six of 166 cases were complicated by pure red-cell aplasia. In 3 of these, the pure red-cell aplasia appeared after surgical intervention. Remission was observed in 2 patients who underwent extended thymectomy. The other 4 patients subsequently died from pure red-cell aplasia. The outcome in patients with pure red-cell aplasia was poorer than that in the entire group of patients with thymoma and in those with thymoma complicated by myasthenia gravis. The possible onset of pure red-cell aplasia after thymectomy should be kept in mind during follow-up.




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