Asian Cardiovasc Thorac Ann 2003;11:198-202
© 2003 Asia Publishing EXchange Ltd
Soluble Adhesion Molecules in Coronary Artery Bypass Surgery
Minxin Wei, MD1,
Jari Laurikka, MD,
Pekka Kuukasjärvi, MD,
Erkki Pehkonen, MD,
Matti Tarkka, MD
Division of Cardiovascular Surgery, Tampere University Hospital, Tampere, Finland
1 Division of Cardiovascular Surgery, The First Affiliated Hospital of Zhongshan University, Guangzhou, People’s Republic of China
For reprint information contact: Matti Tarkka, MD Tel: 358 3 247 6378 Fax: 358 3 247 5756 email: matti.tarkka{at}tays.fi Division of Cardiovascular Surgery, Tampere University Hospital, PO Box 2000, Fin-33521 Tampere, Finland.
Plasma levels of sE-selectin, sP-selectin, and sICAM-1 were measured before anesthesia and at 0.5, 4, and 20 hours after cardiopulmonary bypass in 37 men undergoing coronary artery bypass surgery. Plasma sE-selectin remained close to the preoperative levels. The levels of sP-selectin increased significantly from 46.5 ± 15.3 ng•mL-1 to 69.3 ± 39.6 ng•mL-1 at 0.5 hours, 84.1 ± 45.5 ng•mL-1 at 4 hours, and 79.6 ± 35.5 ng•mL-1 at 20 hours. Plasma sICAM-1 levels decreased 0.5 hours after cardiopulmonary bypass, recovered at 4 hours, and showed a significant increase at 20 hours. The changes in plasma levels of adhesion molecules did not correlate with the duration of bypass or aortic crossclamping, hemodynamics, or creatine kinase-MB levels. However, sE-selectin and sICAM-1 levels increased considerably more in patients who needed norepinephrine in the intensive care unit. These results indicate that the transient changes in plasma levels of soluble adhesion molecules are not associated with postoperative myocardial injury in low-risk coronary grafting, although they correlate with the need for a vasopressor.
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