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Asian Cardiovasc Thorac Ann 2004;12:173-181
© 2004 Asia Publishing EXchange Ltd

REVIEW PAPER

Therapeutic Angiogenesis Using Vascular Endothelial Growth Factor

Lei Ye, MD, Husnain K Haider, PhD1, Shu-Jia Jiang, MD, Eugene KW Sim, FRCS

Department of Cardiothoracic and Vascular Surgery
1 National University Medical Institutes, Clinical Research Centre, National University of Singapore, Singapore

For reprint information contact: Eugene KW Sim, FRCS Tel: 65 6772 5214 Fax: 65 6776 6475 Email: sursimkw{at}nus.edu.sg Dept. of Cardiothoracic & Vascular Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074

Therapeutic angiogenesis using vascular endothelial growth factor can reduce tissue ischemia by simulating the natural process of angiogenesis. Vascular endothelial growth factor not only stimulates endothelial cells to proliferate and migrate, but also mobilizes endothelial progenitor cells and achieves vascular protection. Besides direct administration of angiogenic proteins, plasmids and viral vectors carrying angiogenic genes have been used. Animal experiments have shown promise with evidence of neovascularization and improved perfusion in the target myocardium. Initial phase I and II clinical trials results are encouraging and reflect the potential success of therapeutic angiogenesis as a clinical modality for the treatment of ischemic heart disease. This review discusses the role of vascular endothelial growth factor in therapeutic angiogenesis, along with the problems and considerations of this approach as a treatment strategy.






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