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Asian Cardiovasc Thorac Ann 2004;12:95-98
© 2004 Asia Publishing EXchange Ltd

ORIGINAL CONTRIBUTION

Fungal Endocarditis: An Autopsy Study

Sundaram Challa, MD, Aruna Kumari Prayaga, MD, Laxmi Vemu, MD, Jaishankar Sadasivan, MD, Murali Krishna Murthy Jagarlapudi, MD, Raghunadharao Digumarti, MD, Rajagopal Prabhala, MS

Nizam’s Institute of Medical Sciences, Hyderabad, India Institute of Neurological Sciences Care Hospital, Hyderabad, India

For reprint information contact: Sundaram Challa, MD Tel: 91 40 2332 0332 Fax: 91 40 2331 0076 Email: challa_sundaram{at}yahoo.com Nizam’s Institute of Medical Sciences, Panjagutta, Hyderabad 500 082, Andhra Pradesh, India.

Between 1990 and 2002, 237 hearts were examined at autopsy, including 16 with infective endocarditis; 6 showed fungal endocarditis. The preceding pathology was chronic rheumatic heart disease in 2 patients, one of whom had undergone double valve replacement, 2 patients had been treated for acute lymphoblastic leukemia, and one had protein-energy malnutrition. The underlying cause was unknown in one case. The organisms isolated were Aspergillus in 3 patients, Zygomycota in 1, Candida in 1, and both Candida tropicalis and Aspergillus in 1 patient. Immunosuppressed states are a cause of fungal endocarditis in India, although chronic rheumatic heart disease is the preceding pathology in the majority of patients.




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[Abstract] [Full Text] [PDF]


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