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Asian Cardiovasc Thorac Ann 2004;12:350-356
© 2004 Asia Publishing EXchange Ltd

ORIGINAL CONTRIBUTION

Multiple Purpose Simulator Using a Natural Porcine Mitral Valve

Makoto Arita, MS1, Sumihiro Tono, MS, Hitoshi Kasegawa, MD2, Mitsuo Umezu, PhD

1 Advanced Research Institute for Science and Engineering
Department of Mechanical Engineering, Waseda University
2 Department of Cardiovascular Surgery, The Sakakibara Heart Institute, Tokyo, Japan

For reprint information contact: Makota Arita, MS Tel: 81 3 5286 3256 Fax: 81 3 3200 2516 Email: arita{at}kurenai.waseda.jp Advanced Research Institute for Science and Engineering, Waseda University, 3-4-1, Ohkubo, Shinjuku-ku, Tokyo 169-85555, Japan.

An in vitro pulsatile simulator with a porcine mitral valve was developed in order to simulate physiologic and diseased mitral valve conditions. Evaluation of these conditions was conducted from a hydrodynamic and annulus behavior point of view. We found it possible to simulate mild "mitral valve prolapse" and to obtain quantitative data related to the condition. The diseased condition produced a 40% greater regurgitant volume than that observed under the normal condition ( p < 0.0001). Regarding the leakage volume, the diseased condition exhibited about 2.6 times more leakage than the normal condition. The mitral valve simulator proposed in this study is considered fairly stable with respect to both hemodynamics and the behavior of the annulus, and it is an adequate simulator for modeling various types of normal and diseased mitral valve conditions.






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