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Renin-Angiotensin System Polymorphisms and Coronary Artery Surgery Patients

Department of Cardiovascular Surgery, Ankara Numune Education and Research Hospital
¹ Metis Biotechnology Ltd.
² Department of Cardiovascular Surgery, TYIH, Ankara, Turkey

For reprint information contact: Kanat Ozisik, MD Tel: 90 505 290 1885 Fax: 90 312 310 3460 Email: sozisik2002{at}yahoo.com, 23.cad Kirkkonaklar mah. Simkent Sitesi 2.Blok No:6/13, 06610 Ankara, Turkey.

The frequencies of angiotensin-converting enzyme gene insertion/deletion, angiotensinogen-M253T, and angiotensin II type 1 receptor-A1166C polymorphisms were analyzed in 105 patients undergoing coronary artery bypass grafting (group 1) and a control group of 105 non-cardiac patients (group 2). Blood samples were obtained for biochemical analyses and DNA extraction. Genotyping was performed by polymerase-chain-reaction-based restriction analysis. According to the angiotensin-converting enzyme gene insertion/deletion polymorphism, 36.3% of patients in group 1 and 30.7% in group 2 were homozygous for the DD allele. This difference was not statistically significant. Angiotensin II type 1 receptor-A1166C genotype polymorphism was also not significantly different between the groups. The results showed the angiotensinogen-M235T polymorphism to be heterogenous. The MM homozygote frequency was significantly higher in controls (72.3%), whereas 80% of the TT homozygote frequency was in the surgical group ( p = 0.001). These results show that although there were no significant differences in angiotensin-converting enzyme gene insertion/deletion and angiotensin II type 1 receptor-A1166C genotype polymorphisms between the groups, angiotensinogen-M235T polymorphism of TT homozygote frequency was significantly associated with patients undergoing coronary artery bypass surgery.

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