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Asian Cardiovasc Thorac Ann 2006;14:60-62
© 2006 Asia Publishing EXchange Ltd

CASE STUDIES

A Lethal Complication of Propofol

Hon Chi Suen, MD, Robert J Haake, MD1, Victor M Chavez, MD2, Sultan A Hayat, MD3

Department of Cardiothoracic Surgery
1 Department of Nephrology
2 Department of Pulmonology
3 Department of Cardiology, Memorial Hospital, Belleville, USA

For reprint information contact: Hon Chi Suen, MD Tel: 1 618 233 5722 Fax: 1 618 233 7069 Email: HSUEN{at}earthlink.net, Cardiothoracic Surgery Associates, S.C., 12B Park Place, Swansea, IL 62226, USA

High-dose propofol infusion for sedation of patients in the intensive care unit can result in rhabdomyolysis, acute renal failure, metabolic acidosis, hyperkalemia, ventricular arrhythmia, hyperthermia, and death. The death of a patient with such complications after lung biopsy is reported. Until a safer dosage range has been determined, propofol infusion at rates higher than 5 mg·kg–1·h–1 should be discouraged for long-term sedation (> 48 h).






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