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Non-Infectious Aortitis: an Important Cause of Severe Aortic Regurgitation

Department of Cardiology
¹ Department of Pathology
² Department of Surgery Grantham Hospital Hong Kong, China

For reprint information contact: Elaine MC Chau, FRCP Tel: 852 2518 2612 Fax: 852 2518 8558 Email: echau{at}hkucc.hku.hk, Department of Cardiology, Grantham Hospital, 125 Wong Chuk Hang Road, Hong Kong, China.

From 1995 to 2004, 13 patients with severe aortic regurgitation due to non-infectious aortitis underwent aortic valve surgery at our center. Twenty-eight operations (18 aortic valve replacements and 10 Bentall procedures including 1 aortic root replacement with a homograft) were performed due to a high incidence of prosthetic valve or valved conduit dehiscence (54%). Steroid therapy reduced the incidence of re-operation for anastomotic dehiscence within one year from 90% to 18%. Strategies to prevent dehiscence of the prosthetic aortic valve, which include institution of immunosuppression, replacement of the diseased aorta, and monitoring inflammatory indices, are discussed.

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