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Shigetoshi Mieno
Hitoshi Horimoto
Shinjiro Sasaki
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Asian Cardiovasc Thorac Ann 2006;14:239-243
© 2006 Asia Publishing EXchange Ltd

ORIGINAL CONTRIBUTIONS

Landiolol Enhances Effect of Ischemic Preconditioning in Isolated Rabbit Hearts

Shigetoshi Mieno, MD, Hitoshi Horimoto, MD, Kenji Kishida, MD, Sachiko Horimoto, MD, Shinjiro Sasaki, MD

Department of Thoracic and Cardiovascular Surgery Osaka Medical College Osaka, Japan

For reprint information contact: Shigetoshi Mieno, MD Tel: 81 72 683 1221 Fax: 81 72 684 6542 Email: tho050{at}poh.osaka-med.ac.jp, Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, 2-7 Daigakucho, Takatsuki, Osaka 569-8686, Japan

The effect of the ultra-short-acting beta blocker, landiolol, on ischemic preconditioning was examined in isolated rabbit hearts. Ischemic preconditioned hearts received 2 episodes of 5 min each of global ischemia and reperfusion. The left anterior descending coronary artery was occluded for 1 hour and reperfused for 1 hour. Left ventricular end-systolic and end-diastolic pressures and infarct size were measured. Seven control hearts had no drug infused. Four groups of 6 hearts each were pretreated with 1 or 3 µM of landiolol or a combination of 1 or 3 µM landiolol and ischemic preconditioning. A further group of 6 hearts had ischemic preconditioning without landiolol. Ischemic preconditioning significantly reduced left ventricular end-diastolic pressure and infarct size compared to the controls. Landiolol alone did not change left ventricular end-diastolic pressure or infarct size, but landiolol 3 µM and ischemic preconditioning decreased left ventricular end-diastolic pressure more than preconditioning alone. These data suggest that pre-ischemic landiolol infusion may enhance the cardioprotective effect of ischemic preconditioning.






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