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Asian Cardiovasc Thorac Ann 2006;14:254-260
© 2006 Asia Publishing EXchange Ltd

REVIEW PAPER

Pathobiology of Idiopathic Ascending Aortic Aneurysms

EW Matthias Kirsch, MD, N Costin Radu, MD, Eric Allaire, MD, Daniel Y Loisance, MD

Department of Cardiothoracic Surgery, Hospital Henri Mondor, Créteil Cedex, France

For reprint information contact: EW Matthias Kirsch, MD Tel: 33 1 4981 2172 Fax: 33 1 4981 2152 email: matthias.kirsch{at}hmn.aphp.fr, Department of Cardiothoracic Surgery, Hospital Henri Mondor, 51 Avenue Mal de Lattre de Tassigny, Créteil Cedex 94 000, France.

The majority of ascending aortic aneurysms cannot be related to any specific etiology and should be qualified as idiopathic. The pathobiology of ascending aortic aneurysms remains incompletely understood. Data from direct study are still scarce and often limited because of patient heterogenicity. Currently available information suggests that destructive remodeling of the aortic wall, inflammation and angiogenesis, biomechanical wall stress, and molecular genetics are relevant mechanisms of idiopathic ascending aortic aneurysm formation and progression. Further understanding of these mechanisms will likely provide novel diagnostic, prognostic, and therapeutical tools for the clinician.




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E.W. M. Kirsch, N. C. Radu, M. Gervais, E. Allaire, and D. Y. Loisance
Heterogeneity in the remodeling of aneurysms of the ascending aorta with tricuspid aortic valves.
J. Thorac. Cardiovasc. Surg., November 1, 2006; 132(5): 1010 - 1016.
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