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Paulo C Santos
Ivan Casagrande
Ênio Buffolo
David T Cheung
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Asian Cardiovasc Thorac Ann 2007;15:413-417
© 2007 Asia Publishing EXchange Ltd

ORIGINAL CONTRIBUTIONS

Stentless Valves Treated by the L-Hydro Process in the Aortic Position in Sheep

Paulo C Santos, MD, Luís R Gerola, MD, Ivan Casagrande, MD1, Ênio Buffolo, PhD, David T Cheung, PhD

Department of Cardiovascular Surgery, Escola Paulista de Medicina (UNIFESP), São Paulo
1 Research Center of Labcor, Belo Horizonte, Brasil

For reprint information contact: Paulo C Santos, MD, Tel: 55 34 3235 0167, Fax: 55 34 3235 0020, Email: paulocir{at}hotmail.com, Rua Bernardo Cupertino 704, Martins, Uberlândia, MG, Brazil 38400-444.

Calcification of glutaraldehyde-treated bioprosthetic heart valves is a major cause of long-term failure. We studied porcine aortic valves treated by the L-Hydro process and implanted into 14 juvenile sheep (group 1). Another 10 sheep were implanted with glutaraldehyde-treated porcine bioprostheses (group 2). The animals were sacrificed after 150 days and the explanted valves were analyzed for calcification. Hemodynamic measurements by echocardiography and angiography were carried out prior to sacrifice. Macroscopic analysis showed calcification and loss of mobility of the leaflets in all group 2 implants and in one group 1 implant. Light microscopy showed foci of calcification in all group 2 implants and in 3 valves from group 1. A significant reduction in the level of calcification was found in porcine bioprostheses treated by the L-Hydro process and implanted into the juvenile sheep model.






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