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Benefits of a ß-Blocker for Intractable Hemolysis due to Paraprosthetic Leakage

Department of Surgery, Kurume University School of Medicine, Kurume, Japan

For reprint information contact: Shigeaki Aoyagi, MD, Tel: 81 94 235 3311, Fax: 81 94 235 8967, Email: aoyagi{at}med.kurume-u.ac.jp, Department of Surgery (2), Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.

We describe a 58-year-old man who was successfully treated with a ß-adrenergic receptor blocking agent for intractable hemolysis due to paraprosthetic leakage. After replacement of a mitral prosthetic valve with another mechanical valve, the patient suffered intractable intravascular hemolysis resulting from recurrent paraprosthetic leakage. With oral administration of a ß-adrenergic receptor blocker, betaxolol hydrochloride, for 3 months, the hemoglobin value increased from 9.7 g·dL^–1 to 12.4 g·dL^–1, although glutamic oxaloacetic transaminase and lactic dehydrogenase values remained elevated.