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Asian Cardiovasc Thorac Ann 2008;16:4-6
© 2008 Asia Publishing EXchange Ltd

ORIGINAL CONTRIBUTIONS

Di(2-ethylhexyl) Phthalate Exposure During Cardiopulmonary Bypass

Yosuke Takahashi, MD, Toshihiko Shibata, MD, Yasuyuki Sasaki, MD, Hiromichi Fujii, MD, Yasuyuki Bito, MD, Shigefumi Suehiro, MD

Department of Cardiovascular Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan

For reprint information contact: Yosuke Takahashi, MD, Tel: 81 6 6645 3980, Fax: 81 6 6646 3071, Email: ysk{at}msic.med.osaka-cu.ac.jp, Department of Cardiovascular Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.

Di(2-ethylhexyl) phthalate is an excellent plasticizer for polyvinyl chloride but a known endocrine disrupting chemical. To investigate whether tubing containing no diethylhexyl phthalate reduces the overall extraction of this plasticizer during cardiopulmonary bypass, 16 patients undergoing coronary artery bypass grafting were randomly divided into 2 groups of 8 each. Group A had tubing containing diethylhexyl phthalate in the circuit, and group B had no diethylhexyl phthalate in the tubing. The plasma diethylhexyl phthalate level at the end of cardiopulmonary bypass was significantly increased compared to before anesthesia in both groups (group A: 103 ± 60 to 2,094 ± 1,046 ng·mL–1; group B: 135 ± 60 to 472 ± 141 ng·mL–1), and it was significantly higher in group A than group B. This study demonstrates that using tubing free from diethylhexyl phthalate significantly reduces the release of this agent during cardiopulmonary bypass, which may minimize exposure to diethylhexyl phthalate.






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