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Sumit Narang
Amit Banerjee
Deepak K Satsangi
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ORIGINAL ARTICLE

Seasonal Variation in Thrombogenicity of Blood: a Word of Caution

Sumit Narang, MS, Amit Banerjee, MCh, Deepak K Satsangi, MCh, Mohammad A Geelani, MCh

Department of Cardiovascular and Thoracic Surgery, GB Pant Hospital, Maulana Azad Medical College, New Delhi, India

Sumit Narang, MS Tel: +91 129 4086920 Fax: +91 11 26672594 Email: sumit_narang{at}yahoo.com, House No. 127, Sector 7 A, Faridabad, Haryana 121006, India.

ABSTRACT

Thrombogenicity of blood is known to have seasonal variations. The clinical implications of seasonal variations in the anticoagulation profile of patients with mechanical valves was assessed. Data of patients implanted with a mechanical heart valve for more than 3 months were collected at follow-up or on presentation to the emergency department. The mean time from the previous follow-up examination was 3.6 ± 0.3 months. The number of patients with an international normalized ratio >3.5 and the incidence of hemorrhagic events peaked in hottest part of the year (June–July), with 128 cases of prolonged clotting and 43 hemorrhagic events in this period. The number of patients with rapid clotting and the incidence of embolic events peaked in coldest part of the year (December–January), with 120 cases of international normalized ratio <1.5 and 37 embolic events in this period. There was a significant correlation between temperature and thrombogenicity in patients with prosthetic heart valves on long-term anticoagulation.

Key Words: Anticoagulants • Heart Valve Prosthesis • Seasons

Asian Cardiovasc Thorac Ann 2009; 17:25-28
© 2009 by SAGE Publications
DOI: 10.1177/0218492309102625




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