Asian Annals
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Gláucio Furlanetto
Carlos H Passerino
Sidney Levitsky
Ivan S J Casagrande
Right arrow Permission Requests
Google Scholar
Right arrow Articles by Furlanetto, G.
Right arrow Articles by Casagrande, I. S J
PubMed
Right arrow PubMed Citation
Right arrow Articles by Furlanetto, G.
Right arrow Articles by Casagrande, I. S J

ORIGINAL ARTICLE

Biointegration and Growth of Porcine Valved Pulmonary Conduits in a Sheep Model

Gláucio Furlanetto, MD, Carlos H Passerino, MD, Rolland Siegel, David T Chueng, PhD, Sidney Levitsky, MD, Ivan S J Casagrande, MD

Centro de Pesquisas Labcor Laboratórios Belo Horizonte, Minas Gerais, Brazil

Gláucio Furlanetto, MD Tel: +55 11 3284 7686 Fax: +55 11 3284 7686 Email: gfurlanetto{at}terra.com.br, Rua Maestro Cardim 560, Sala 73, Liberdade, CEP 01323-000 São Paulo, SP, Brazil.

ABSTRACT

As there is currently no suitable valved pulmonary conduit for small children, porcine conduits treated by the L-Hydro process were implanted into 9 newborn lambs to investigate growth potential. Of the 8 survivors, 7 were kept alive for 12 months after implantation. The diameter of the conduit and gradient across the valve were evaluated at surgery and at 3 and 9 months postoperatively using bidirectional echocardiographic and angiographic methods. After sacrifice, histological and radiological analyses were performed. The mean weight of the animals was 4.2 ± 1.1 kg at implantation and 43.1 ± 6.2 kg at sacrifice. There was a significant increase in mean valve area from 139.9 ± 18.0 mm2 at implantation to 443.5 ± 89.2 mm2 at 12 months. Pre-sacrifice angiography showed no transvalvular gradient, and radiographic analysis did not reveal significant conduit wall or leaflet calcification in any of the animals. Histological examination of the grafts demonstrated total integration, with native-like intact valve leaflets. Thus functional evaluation, echocardiography, and histology demonstrated growth of the grafts with completely endothelialized and apparently normal pulmonary valve leaflets without calcification.

Key Words: Bioprosthesis • Heart Defects • Congenital • Pulmonary Valve • Tissue Engineering

Asian Cardiovasc Thorac Ann 2009; 17:350-356
© 2009 by SAGE Publications
DOI: 10.1177/0218492309338096




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2009 by SAGE Publications