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ORIGINAL ARTICLE

Is 6% Hydroxyethyl Starch 130/0.4 Safe in Coronary Artery Bypass Graft Surgery?

Joanna Ooi Su Min, MMed(Anaes), Abdul Rahman Mohd Ramzisham, MS1, Mohd Dimon Zamrin, MS1

Division of Cardiothoracic Anaesthesia
1 Division of Cardiothoracic Surgery, Heart and Lung Centre, Hospital Universiti Kebangsaan Malaysia Kuala Lumpur, Malaysia

Joanna Ooi Su Min, MMed(Anaes) Tel: +603 91455555 Ext 5852 Fax: +603 91737826 Email: joanna{at}ppukm.ukm.my, Department of Anaesthesiology & Intensive Care, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia.

ABSTRACT

The aim of this study was to compare 6% hydroxyethyl starch 130/0.4 with 4% succinylated gelatin for priming the cardiopulmonary bypass circuit and as volume replacement in patients undergoing coronary artery bypass, in terms of postoperative bleeding, blood transfusion requirements, renal function, and outcome after surgery. Forty-five patients received 6% hydroxyethyl starch 130/0.4 (Voluven) and another 45 were given 4% succinylated gelatin (Gelofusine) as the priming solution for the cardiopulmonary bypass circuit as well as for volume replacement. Postoperative bleeding was quantified from the hourly chest drainage in the first 4 h and at 24 h postoperatively. The baseline characteristics of both groups were similar. In the hydroxyethyl starch group, the total amount of colloid used was 1.9 ± 1.0 L, while the gelatin group had 2.0 ± 0.7 L. There was no significant difference in hourly chest drainage between groups. Blood transfusion requirements, estimated glomerular filtration rate, extubation time, intensive care unit and hospital stay were similar in both groups. It was concluded that 6% hydroxyethyl starch 130/0.4 is a safe alternative colloid for priming the cardiopulmonary bypass circuit and volume replacement in patients undergoing coronary artery bypass surgery.

Key Words: Cardiopulmonary Bypass • Coronary Artery Bypass • HES 130/0.4 [Voluven] • succinylated gelatin [Gelofusine]

Asian Cardiovasc Thorac Ann 2009; 17:368-372
© 2009 by SAGE Publications
DOI: 10.1177/0218492309338101




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