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Juan C Chachques
Olivier Jegaden
Thierry Mesana
Yves Glock
Pierre A Grandjean
Alain F Carpentier
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ORIGINAL ARTICLE

Cardiac Bioassist: Results of the French Multicenter Cardiomyoplasty Study

Juan C Chachques, MD1, Olivier Jegaden, MD2, Thierry Mesana, MD3, Yves Glock, MD4, Pierre A Grandjean, MS5, Alain F Carpentier, MD1 for the French Cardiomyoplasty Investigators

1 Department of Cardiovascular Surgery, Pompidou Hospital, Paris, France
2 Department of Cardiovascular Surgery, Louis Pradel Hospital, Lyon, France
3 Department of Cardiovascular Surgery, La Timone Hospital, Marseille, France
4 Department of Cardiovascular Surgery, Rangueil Hospital, Toulouse, France
5 Bakken Research Center, Maastricht, The Netherlands

Juan C Chachques, MD, Tel: +33 613144398, Fax: +33 140728608, Email: j.chachques{at}brs.aphp.fr, Department of Cardiovascular Surgery, Pompidou Hospital, 20 rue Leblanc, 75015 Paris, France.

ABSTRACT

The French multicenter experience (6 centers) of dynamic cardiomyoplasty was analyzed for long-term survival and functional outcome, the most important endpoints in congestive heart failure therapy. Cardiomyoplasty was performed in 212 patients with symptoms of chronic heart failure despite maximal pharmacological therapy. The etiology was ischemic (48%), idiopathic (45%) or other (7%). Cardiomyoplasty was performed using the latissimus dorsi muscle which was electrostimulated after surgery. During follow-up, 88% of patients improved clinically. Hospital death occurred in 29 (14%) patients and was related to the severity of preoperative heart failure symptoms. Late mortality occurred in 99 patients due to heart failure (44%), sudden death (37%), or noncardiac causes (18%). Combined dynamic cardiomyoplasty and implantation of a cardiac rhythm management system was safely achieved in 22 patients, and 26 underwent heart transplantation for recurrent heart failure. Long-term functional improvements were observed in most patients, and the best outcome was achieved in those with isolated right ventricular failure. Dynamic cardiomyoplasty can be considered as a destination therapy or a mid- to long-term biological bridge to heart transplantation.

Key Words: Cardiomyoplasty • Cardiomyopathies • Heart Failure • Myocardial Ischemia

Asian Cardiovasc Thorac Ann 2009; 17:573-580
© 2009 by SAGE Publications
DOI: 10.1177/0218492309349371




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