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ORIGINAL ARTICLE

Risk Factors for Mediastinitis and Endocarditis after Cardiac Surgery

Javier Gualis, MD, Santiago Flórez, MD, Eduardo Tamayo, MD, Francisco Javier Álvarez, MD, Javier Castrodeza, MD, Mario Castaño, MD

Department of Cardiac Surgery, Valladolid University Hospital, Valladolid, Spain

Javier Gualis, MD, Tel: +34 987234900 Ext 2382, Fax: +34 987243924, Email: javgua{at}hotmail.com, Department of Cardiac Surgery, Valladolid University Hospital, Valladolid, Spain.

ABSTRACT

A prospective open-cohort study was performed in 838 adults undergoing coronary revascularization or valve surgery to define the risk factors for development of surgical site infections. Patients diagnosed with mediastinitis or endocarditis during follow-up were compared with patients with no such infection. After 1 year of follow-up, 22 (2.6%) patients had developed mediastinitis or endocarditis. No preoperative or intraoperative variables were identified as risk factors. By multivariate analysis of postoperative variables, respiratory insufficiency, microorganisms in blood cultures, and intensive care unit stay were independent risk factors for the development of these complications. The type of antibiotic prophylaxis had no influence on the incidence of organ or space infections after cardiac surgery.

Key Words: Anti-Bacterial Agents • Cefazolin • Endocarditis • Mediastinitis • Surgical Wound Infection

Asian Cardiovasc Thorac Ann 2009; 17:612-616
© 2009 by SAGE Publications
DOI: 10.1177/0218492309349071




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