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Serotonin: Ubiquitous Neuromodulator in the Failing Heart

Division of Clinical & Experimental Medicine Central Drug Research Institute, Lucknow, India 1 Department of Medicine, 2 Department of Pharmacology KG Medical College, Lucknow, India

Ashim Ghatak, MD Division of Clinical & Experimental Medicine Central Drug Research Institute Chattar Manzil, Post Box No. 173 Lucknow 226001, India Tel:91 522 21 2411 Fax:91 522 22 3405 or 22 3938 Email: root{at}cscdri.ren.nic.in

Serotonin exhibits various cardiovascular effects and evidence of its role in various cardiovascular disorders is emerging. Serotonin levels in whole blood and the platelet serotonin uptake were significantly increased in patients with heart failure compared to control subjects. However, the intraplatelet serotonin content was not significantly different in the two groups. We conclude that serotonin is involved in the syndrome of heart failure both directly and indirectly through its action on cardiac contractility, heart rate, preload, and afterload.