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Effects of Pregnancy on Long-Term Follow-Up of Mitral Valve Bioprostheses

Mustafa Emir, MD, Gürkan Uzunonat, MD, Birol Yamak, MD, A Tulga Ulus, MD, M Kamil Göl, MD, Zafer Iscan, MD, S Fehmi Katirciolu, MD, Binali Mavita, MD, Ouz Tademir, MD, Kemal Bayazit, MD

Department of Cardiovascular Surgery Türkiye Yüksek htisas Hospital Ankara, Turkey

For reprint information contact: Birol Yamak, MD Department of Cardiovascular Surgery Türkiye Yüksek Ihtisas Hospital Sihhiye, Ankara 06100, Turkey Tel: 90 312 310 3080 Ext. 1247 Fax: 90 312 466 3202 E-mail: ulus{at}escortnet.com

Between 1986 and 1990, 304 females between 11 and 45 (mean, 33.9 ± 6.9) years of age underwent isolated mitral valve replacement with a bioprosthesis. Thirty-nine of the 285 survivors experienced 48 pregnancies during the late follow-up period (group 1). Structural valve deterioration occurred in 25 (64.1%) of these patients and in 70 (28.4%) of the 246 patients (group 2) who did not become pregnant (p < 0.01). The mean time at which structural valve deterioration occurred was 7.01 ± 1.19 years postoperatively (range, 4.74 to 8.36 years) for group 1 patients and 6.76 ± 1.34 years (range, 2.33 to 10.17 years) for group 2 patients (p > 0.05). Freedom from structural valve deterioration at 10 years was 22.9% ± 8.11% for group 1 and 29.24% ± 6.09% for group 2 (p > 0.05). We concluded that pregnancy did not influence the long-term outcome after mitral valve replacement with a bioprosthesis.