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Asian Cardiovasc Thorac Ann 1999;7:13-17
© 1999 Asia Publishing EXchange Pte Ltd

ORIGINAL CONTRIBUTION

Thyroid Hormone and Myocardial Metabolism After Heart Surgery in Dogs

Noriyuki Murai, MD, Yasushi Katayama, MD, Takashi Yamada, MD, Takao Imazeki, MD, Yoshihito Irie, MD, Hiroshi Kiyama, MD, Yasuhiro Sato, MD, Ikkoku Hata, MD, Hirotugu Yoshida, MD, Mikaya Mukouyama

Department of Cardiovascular & Thoracic Surgery Dokkyo University School of Medicine Koshigaya Hospital Saitama, Japan
For reprint information contact: Noriyuki Murai, MD Tel: 81 489 65 1111 Fax: 81 489 60 1506 email: shinpais{at}po.iijnet.or.jp Department of Cardiovascular & Thoracic Surgery, Dokkyo University School of Medicine, Koshigaya Hospital, 2-1-50 Minamikoshigaya, Koshigaya, Saitama 343-8555, Japan.
Recent studies have demonstrated that thyroid hormone improves hemodynamics following open-heart surgery, through unknown mechanisms. The effect of triiodothyronine on myocardial metabolism was studied in dogs undergoing normothermic crystalloid cardioplegic arrest. Seven animals in group 0 served as controls, 8 in group 1 received 0.1µg•kg–1•min–1 triiodothyronine intravenously after aortic cross-clamping, and 3 dogs in group 2 received triiodothyronine 150 µg per day orally for 7 days preoperatively and intravenously (0.1 µg•kg–1•min–1) after aortic cross-clamping. Myocardial carbon dioxide production and the uptake of oxygen, lactate, glucose, and free fatty acids were determined before aortic cross-clamping and at 10, 30, 60, and 120 minutes after declamping. After aortic cross-clamping, increased myocardial uptake of oxygen, lactate, and glucose were observed in group 1 compared with group 0. Myocardial free fatty acid uptake decreased in all groups. Carbon dioxide production correlated with myocardial oxygen uptake. These findings suggest that intraoperative triiodothyronine supplementation improves myocardial metabolism but preoperative administration is ineffective.






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