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Beneficial Effects of Aminophylline on Ischemia-Reperfusion in Isolated Rabbit Heart

A Tulga Ulus, MD, Perran Gökçe, PhD^,1, Eser Özgencil, PhD^,1, Ülkü Yildiz, MD, Erdogan Ibriim, MD^,2, S Fehmi Katirciolu, MD

Department of Cardiovascular Surgery Türkiye Yüksek htisas Hospital Ankara, Turkey 1 The Veterinary Faculty University of Ankara Ankara, Turkey 2 Department of Cardiovascular Surgery Süleyman Demirel University Isparta, Turkey

For reprint information contact: A Tulga Ulus, MD Tel: 90 312 310 3080 Fax: 90 312 229 5868 email: ulus{at}escortnet.com Nigde sok Ulus ap. 20/6, Dikmen, Ankara 06460, Turkey.

Eighteen rabbit hearts were arrested for 3 hours with cardioplegic solution at 4°C, followed by reperfusion with oxygenated perfusion solution at 37°C for 2 hours. Six control hearts received no drug during arrest or reperfusion (group 1). Six hearts received 3 mg•L^–1 aminophylline during the arrest period (group 2). Six hearts received 3 mg•L^–1 aminophylline during the reperfusion period (group 3). Effects of aminophylline were evaluated in terms of the pressure-volume relationship, coronary flow, myocardial oxygen extraction, and lactate release before cardioplegic arrest and after 1 and 2 hours of reperfusion. End-diastolic pressure at constant volume after 2 hours of reperfusion was 19 ± 2.63 mm Hg in group 1, 14 ± 1.7 mm Hg in group 2, and 19 ± 2.55 mm Hg in group 3 (p < 0.05 for group 2 versus groups 1 and 3). End-systolic pressure at constant volume after 2 hours of reperfusion was 81 ± 3.55 mm Hg in group 1, 90 ± 2.95 mm Hg in group 2, and 84 ± 3.47 mm Hg in group 3 (p < 0.05 for group 2 versus groups 1 and 3). Oxygen extraction was significantly higher and release of lactate was significantly lower in group 2 compared to groups 1 and 3. The results indicate that aminophylline administration during cardioplegic arrest improved systolic and diastolic function and had a beneficial effect on metabolic recovery.

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