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Taurine Potentiates the Efficacy of Hypothermia

Research Department Kokura Memorial Hospital Kitakyushu-shi, Fukuoka, Japan

For reprint information contact: Tadaomi-Alfonso Miyamoto, MD Tel: 81 93 951 6582 Fax: 81 93 921 8497 Research Department, Kokura Memorial Hospital, 1-1 Kifune-cho, Kokura-kitaku, Kitakyushu-shi, Fukuoka 802, Japan.

To assess the protective effect of exogenous taurine on the central nervous system, spinal cord ischemia was induced for 60 minutes in 16 rabbits randomized into 3 groups. Group 1 (n = 5) had hypothermia targeted to 30.5°C and 10 mmol•kg^–1 taurine, group 2 (n = 5) had hypothermia targeted to 29.5°C, and group 3 (n = 6) had hypothermia targeted to 30°C. Group 1 was cooled to 30.6 ± 0.07°C and group 2 was cooled to 29.4 ± 0.07°C; both had total functional recovery (rabbits able to keep normal posture, to walk, and to hop) within 6 hours of reperfusion. None of the group 3 animals that were cooled to 29.9 ± 0.05°C recovered function. It was concluded that taurine combined with hypothermia protected the spinal cord from 60 minutes of ischemia at a temperature that could not otherwise ensure protection. The protective effect contributed by taurine was equivalent to 1.2°C.

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