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Asian Cardiovasc Thorac Ann 2001;9:19-23
© 2001 Asia Publishing EXchange Pte Ltd

ORIGINAL CONTRIBUTION

Calcification of Experimental Valve Bioprostheses

Chung Sung Woon, MD, Kim Jong Won, MD, Lee Hyung Ryul, MD, Kim Yeong Dae, MD, Chung Hwang Kiw, MD

Department of Thoracic and Cardiovascular Surgery Pusan National University College of Medicine Pusan, Korea
For reprint information contact: Chung Sung Woon, MD Tel: 82 51 240 7267 Fax: 82 51 243 9389 email: chungsungwoon{at}hanmail.net #1-10 Ami-dong, Seo-ku, Pusan 602-739, Korea.
Bovine pericardial strips, porcine valve strips, and canine valve strips were treated with 0.625% glutaraldehyde and implanted subdermally in rats. Weight and calcium content were examined 9 weeks later. Bovine pericardial strips underwent calcification after implantation; electron microscopy showed concentric electron-dense calcified deposits in the collagen fibers. Implanted porcine valve strips also underwent calcification; electron microscopy showed concentric electron-dense calcified deposits in the interstitium. Calcification was also detected in canine valve strips after implantation, but the proportion of calcium was lower than in the other tissues; electron microscopy showed collagen bundles with speckled calcified granules. The process of calcification started on the surface of the collagen fibrils and in the interfibrillar space. It was concluded that preservation of collagen fibers would be helpful in preventing calcification. The use of canine cardiac valves might improve the durability of bioprostheses.






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