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Hemostatic Markers and Renal Function After Cardiopulmonary Bypass

Mustafa Yilmaz, MD, brahim Haznedarolu, MD^1,, M anser Ate, MD, erafettin Kirazli, MD, PhD^1,, lhan Paaolu, MD

Department of Thoracic and Cardiovascular Surgery 1 Department of Hematology Faculty of Medicine Hacettepe University Sihhiye, Ankara, Turkey
For reprint information contact: Mustafa Yilmaz, MD Tel: 90 312 476 5533 Fax: 90 312 324 3284 email: myilmazmd88{at}turk.net Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara 06100, Turkey.

To evaluate coagulation status after cardiopulmonary bypass and its relation to renal function, thrombin-antithrombin III complex and prothrombin fragment 1+2 were measured as thrombotic markers in 46 patients undergoing coronary artery bypass grafting. Postoperative serum creatinine values exceeded 20 mg•L^–1 in 12 patients, indicating compromised renal function; there was a statistically significant increase in the postoperative levels of thrombotic markers in these patients. These data indicate that patients with renal dysfunction after cardiopulmonary bypass have a thrombotic tendency. Anticoagulant treatment is recommended in such patients.