HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Kâmuran A Kadipasaolu O Howard Frazier Hans-Reinhard Zerkowski Permission Requests Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Baykut, D. Articles by Zerkowski, H.-R. Search for Related Content PubMed Articles by Baykut, D. Articles by Zerkowski, H.-R. Related Collections Myocardial infarction

Intravascular Detection of Ischemia by Near-Infrared Spectroscopy

Doan Baykut, MD, Kâmuran A Kadipasaolu, PhD, Hakki Bölükoglu, MD, Martha-Maria Gebhard, MD, O Howard Frazier, MD, Hans-Reinhard Zerkowski, MD

Cullen Cardiovascular Research Laboratories Texas Heart Institute Houston, Texas, USA
For reprint information contact: Doan Baykut, MD Tel: 41 61 265 2525 Fax: 41 61 265 7324 email: baykutd{at}uhbs.ch Clinic of Cardiac and Thoracic Surgery, Kantonsspital Basel, University Clinics, Spitalstrasse 21, Basel CH-4031, Switzerland.

The interruption of myocardial oxygen supply in acute ischemia alters the O₂ content of coronary venous blood. The oxygenation status of coronary sinus blood was assessed by intravascular application of near-infrared spectroscopy in 10 domestic pigs under in-vivo conditions. Calibration of the catheter was performed in vitro by perfusion of blood with gas mixtures of various O₂ concentrations. The catheter was placed into the coronary sinus, and anterior wall ischemia was induced by temporary occlusion of the left anterior descending coronary artery. Spectroscopic and hemodynamic data were obtained. The main differences between oxygenated and deoxygenated hemoglobin were found with O₂ concentrations < 30%, corresponding to the coronary sinus blood O₂ content. Spectrographs showed variations related to CO₂ concentration, pH, and temperature. Spectral analysis showed significant differences between pre-ischemia and ischemia. Variations in spectrographs could be observed in both in-vitro and in-vivo experiments. The intravascular application of near-infrared spectroscopy is technically feasible and can be used as a reliable tool in detection and follow-up of tissue deoxygenation, particularly in acute myocardial ischemia.